Limited Competition: Development and Renovation of Facilities for Expanding the Breeding Capacity of Specific Pathogen Free Non-Human Primates to Support HIV/AIDS-related Research (C06 Clinical Trial Not Allowed) | PAR 24 033

Opportunity Information: Apply for PAR 24 033

This NIH funding opportunity (PAR-24-033) is a limited-competition, discretionary grant program designed to help eligible U.S.-based research institutions expand the national capacity to breed and produce specific pathogen free (SPF) non-human primates (NHPs) that are supported by NIH and used in HIV/AIDS-related research. The funding is specifically for facility development: applicants may propose either new construction or renovation of existing buildings and animal housing infrastructure, with the central goal of increasing breeding capacity and boosting future SPF NHP production. The program is framed around ensuring that the physical infrastructure keeping these colonies can meet both current demand and anticipated future needs for HIV/AIDS research priorities established by NIH.

A key theme in the announcement is justification and alignment. Proposals are expected to clearly connect the requested construction or renovation work to demonstrated or forecasted research needs for SPF NHPs, and to show how the expanded colony capacity will directly support NIH-prioritized HIV/AIDS research activities. In practice, that means an application should not just describe a building project in isolation, but should explain why additional SPF animals are needed, what gaps exist in current availability, and how the improved facilities will translate into a more reliable or larger pipeline of appropriately screened SPF animals for HIV/AIDS research programs.

The award mechanism is a C06 grant, and the notice explicitly states "Clinical Trial Not Allowed." This signals that the funding is intended for infrastructure rather than conducting clinical trials or human-subjects interventional studies. The activity category is health, and the listing is associated with CFDA 93.352. The agency is the National Institutes of Health, and the opportunity is categorized as a grant rather than a contract or cooperative agreement.

Eligibility is broad across U.S. domestic organizations that can credibly carry out major facility projects tied to biomedical research infrastructure. Eligible applicants include various levels of government (state, county, city/township, special districts), federally recognized tribal governments, certain tribal organizations that are not federally recognized, public housing authorities/Indian housing authorities, independent school districts, and both public and private institutions of higher education. The opportunity also allows nonprofit organizations (including both 501(c)(3) and non-501(c)(3) entities), for-profit organizations other than small businesses, and small businesses, as well as other categories specified by NIH. The notice also highlights additional eligible applicant types such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISI), along with faith-based or community-based organizations, eligible federal agencies, regional organizations, and U.S. territories or possessions.

At the same time, the NOFO draws a firm line on foreign involvement in the application. Non-domestic (non-U.S.) entities and foreign institutions are not eligible to apply. Non-domestic components of U.S. organizations are also not eligible to apply, and foreign components (as NIH defines them in the NIH Grants Policy Statement) are not allowed. In other words, the applicant organization and the proposed facility work must be entirely domestic, and the project cannot be structured in a way that routes substantial project activities through foreign components.

From a timing standpoint, the opportunity was created on October 5, 2023, and the original closing date listed is January 7, 2025. The summary information provided does not specify an award ceiling or the expected number of awards, which typically means applicants need to rely on the full NOFO text and NIH guidance for any constraints around budgets, allowable costs, scope, and review considerations. Overall, the program is best understood as an NIH infrastructure investment aimed at strengthening SPF NHP breeding capacity in the United States specifically to support high-priority HIV/AIDS research needs, with proposals expected to be tightly reasoned, needs-driven, and clearly linked to increasing the future availability of SPF animals for NIH-aligned research.

• The National Institutes of Health in the health sector is offering a public funding opportunity titled "Limited Competition: Development and Renovation of Facilities for Expanding the Breeding Capacity of Specific Pathogen Free Non-Human Primates to Support HIV/AIDS-related Research (C06 Clinical Trial Not Allowed)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.352.
• This funding opportunity was created on 2023-10-05.
• Applicants must submit their applications by 2025-01-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

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